From San Diego Intl. Airport:

Take Interstate 5 north to La Jolla Parkway (used to be Ardath Road) exit. (Be careful, do not get on 52 East). Follow La Jolla Parkway west. It will become Torrey Pines Road. Turn right on Prospect Street. La Valencia Hotel is about 1/2 mile on the right. Pull in front of the Hotel for valet parking.

From Los Angeles:

Take Interstate 5 south to La Jolla Village Drive. Exit and turn right (west). Go to the third light and turn left onto Torrey Pines Road. Turn right on Prospect. La Valencia Hotel is about 1/2 mile on the right. Pull in front of the Hotel for valet parking.